Combining cancer immunotherapy and targeted therapy
نویسندگان
چکیده
منابع مشابه
Universes collide: combining immunotherapy with targeted therapy for cancer.
UNLABELLED There have been significant advances in the past several years with regard to targeted therapy and immunotherapy for cancer. This is highlighted in melanoma, where treatment with targeted therapy (against the BRAF oncoprotein) results in responses in the majority of patients, although the duration of response is limited. In contrast, treatment with immunotherapy results in a lower re...
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Imatinib revolutionized gastrointestinal stromal tumor (GIST) treatment but median-progression-free-survival of unresectable/metastatic disease is < 2 y. B-RAF(V600)-mutated-melanoma responds to vemurafenib dramatically but median-progression-free-survival is < 9 mo. Combining imatinib with immunotherapy (peginterferon α-2b) in GIST showed significant induction of antitumor immunity and highly ...
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ژورنال
عنوان ژورنال: Current Opinion in Immunology
سال: 2013
ISSN: 0952-7915
DOI: 10.1016/j.coi.2013.02.011